Elsevier, iScience, Volume 28, Issue 5, 16 May 2025, 112358
This backstory highlights the importance of interdisciplinary and participatory approaches in advancing the One Health concept, using lessons from an international workshop in Lao PDR to address existing knowledge gaps and improve global health security strategies.
Elsevier, Acta Pharmaceutica Sinica B, Volume 15, April 2025
The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.
Elsevier, Brain Research Bulletin, Volume 223, April 2025
This study demonstrated that physical exercise pretreatment improves recognition memory and enhances structural synaptic plasticity in the hippocampus of Alzheimer’s disease (AD) rats, primarily through the activation of hippocampal TREM2. Blocking TREM2 diminished these neuroprotective effects, indicating that exercise mitigates synaptic injury and cognitive decline in AD via a TREM2-dependent mechanism.
Elsevier, International Journal of Clinical and Health Psychology, Volume 25, 1 April 2025
This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with amnestic mild cognitive impairment (aMCI) and late-life depression (LLD), underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.
Elsevier, Cell Reports Medicine, Volume 6, 15 April 2025
This study identifies two CSF proteomic panels that accurately stage Alzheimer’s pathology, outperform current biomarkers, and predict dementia progression over 10 years, enhancing diagnosis and clinical trial stratification.
Elsevier, Journal of Allergy and Clinical Immunology: In Practice, Volume 13, April 2025
Foods are essential for life, but foods can be life-threatening for people with food allergy. This collection of articles from the April 2025 issue of JACI: In Practice provides up to date information on many important aspects of food allergy
Elsevier, Journal of Allergy and Clinical Immunology: In Practice, Volume 13, April 2025
Foods are essential for life, but foods can be life-threatening for people with food allergy. This collection of articles from the April 2025 issue of JACI: In Practice provides up to date information on many important aspects of food allergy.
Elsevier, Journal of Allergy and Clinical Immunology: In Practice, Volume 13, April 2025
Foods are essential for life, but foods can be life-threatening for people with food allergy. This collection of articles from the April 2025 issue of JACI: In Practice provides up to date information on many important aspects of food allergy
Elsevier, Journal of Allergy and Clinical Immunology: In Practice, Volume 13, April 2025
Foods are essential for life, but foods can be life-threatening for people with food allergy. This collection of articles from the April 2025 issue of JACI: In Practice provides up to date information on many important aspects of food allergy
