Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however, by lingering uncertainty over how to treat the quasi “monogenic” role of apolipoprotein E (APOE).

Dementia can disturb the circadian rhythm more than in normal ageing people. And their biological clock is often not enough stimulated by light.

With growing health risks from rising temperatures in the Global South, the lack of essential indoor cooling is increasingly seen as a dimension of energy poverty and human well-being.

Study objective: We estimate emergency department (ED) use differences across Medicare enrollees of different race/ethnicity who are residing in the same zip codes.

Tay–Sachs disease is an inherited lysosomal storage disease resulting from mutations in the lysosomal enzyme, β-hexosaminidase A, and leads to excessive accumulation of GM2 ganglioside.

Sideroblastic anemia (SA) is characterized by bone marrow ring sideoblasts (RSs). RS reflect abnormal iron accumulation in the mitochondria of erythroblasts. Congenital SA is caused by the mutation of genes involved in iron-heme metabolism. The most frequent form of congenital SA is X-linked SA due to ALAS2 gene mutation.

This Article supports SDG 3 by analysing data from four international cohorts of patients with pulmonary arterial hypertension, a disease caused by rare genetic variants.

The purpose of this Review is to provide evidence for why gender equality in science, medicine, and global health matters for health and health-related outcomes.