This chapter provides an overview of neurodevelopmental disabilities, emphasizing their lifelong impact, diverse etiologies, and the importance of early genetic testing and individualized, context-aware interventions. It aligns with SDG 3 (Good Health and Well-being) by promoting comprehensive care and lifelong health planning, and SDG 10 (Reduced Inequalities) by advocating equitable access to diagnostic tools, targeted treatments, and inclusive approaches that optimize functional and societal participation goals