As one of the most food-insecure countries of the Global South, Ethiopia has experienced significant land-use changes driven by economic development and population growth. This study examined the dynamic land use transitions in Ethiopia during the period 2000–2020 including the socio-economic factors driving land-use transitions and grain demand. Although the sustained growth in international trade coupled with increased productivity has benefited the country's food supply, the food security situation in low-income countries, including Ethiopia, will remain critical in the context of population growth.