The adoption of advanced Healthcare Information Systems and Medical Informatics requires an integrated approach sensitive to various social, economic, political, and cultural factors. The challenges that the adoption and use sophisticated information and communication technologies (ICTs) generate need to be considered too. Smart Data and Data Analytics along with cognitive computing are the promising technologies with great value added for the domain of healthcare. The goal of SDG 3.d is to strengthen the capacity of all countries, in particular developing countries, for early warning, risk reduction and management of national and global health risks (by e.g. Healthcare Information Systems).