This chapter advances the UN SDG Goal 3: Good Health and Goal 10: Reduced Inequalities by discussing the components of a technical infrastructure to support PHM, including data sources (registries, electronic health records), data analytics tools, patient outreach and engagement tools, and patient tracking dashboards along with real-world examples of PHM programs focused on chronic disease management, genetic testing for hereditary cancers, colorectal cancer screening, COVID-19 testing and vaccination, and tobacco cessation.