Elsevier, Principles and Practice of Pediatric Infectious Diseases (Sixth Edition), 2023, Pages 1125-1133.e4This content aligns with Goal 3: Good Health. Hepatitis B prevalence is highest in the WHO Western Pacific Region and the WHO African Region, where 6.2% and 6.1% of the adult population is infected, respectively. In the WHO Eastern Mediterranean Region, the WHO South-East Asia Region, and the WHO European Region, an estimated 3.3%, 2.0%, and 1.6% of the general population is infected, respectively. In the WHO Region of the Americas, 0.7% of the population is infected. Global differences of HBsAg positivity prevalence between males (3.9%) and females (3.5%) are small.