Chen and Holtzman review the emerging roles of both innate and adaptive immunity, their alterations, their interplay, and their contributions to the development and progression of Alzheimer’s disease. They proposed that targeting dysregulated innate and adaptive immune responses in both brain parenchyma and border structures could lead to important therapeutics for preventing and treating the disease.

This Article supports Sustainable Development Goal 3 by assessing the contribution of smoking to the social inequalities in dementia. The results suggest that smoking in midlife does mediate some of this inequality.

This viewpoint supports SDGs 3, 5, 10 and 16, focusing on the drivers of Black maternal mortality and advocating the collection of disaggregated data to support improvements in Black maternal health.

PrEp interventions led by Key populations are more cost effective in delivering these services.

Experts in the field, along with patient representatives from the Sarcoma Patient Advocacy Global Network (SPAGN), met at an international consensus meeting in 2022 to define best clinical practice of tenosynovial giant cell tumour (TGCT). Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life. A global effort is needed to make active systemic treatments available to TGCT patients worldwide and avoid discrimination.

This Article supports SDG 3 by examining the potential impact of WHO's triple-intervention elimination strategy on cervical cancer incidence among women with HIV in South Africa. The authors note that cervical cancer elimination among women with HIV would necessitate more frequent screening (every 3 years).

This Article supports SDG 3 by examining the potential impact of WHO's triple-intervention elimination strategy on cervical cancer incidence among women with HIV in South Africa. The authors note that cervical cancer elimination among women with HIV would necessitate more frequent screening (every 3 years).

This Article supports SDG 3 by highlighting findings from a population-level study of STI burden in Uganda, showing the need for global investment in innovative approaches that simultaneously test and treat HIV and STIs within existing health infrastructure, such as integrated HIV and STI service programmes within the President's Emergency Plan for AIDS Relief programme.

This Article supports SDGs 3 and 10 by showing that, globally, Black women are at higher risk of adverse perinatal outcomes of neonatal death, stillbirth, preterm birth, and small-for-gestational-age babies than White women, even after adjusting for maternal characteristics. Moreover, these racial disparities in perinatal outcomes were consistently observed across all geographical regions.

An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly cross-neutralizing antibodies (bnAbs) without requiring complex sequential immunization regimens to drive the required antibody affinity maturation.