The Sustainable Development Goals call for countries to reduce premature mortality from non-communicable diseases through mental health promotion, prevention, and treatment (Target 3.5) and for health services to be made universally available (Target 3.8). This paper is part of a broad, global effort to build the capacity of health systems in high-need settings to expand access to mental health services by integrating those services into primary care. In South Africa, nurses are at the heart of this integration effort, and our goal was to learn how best to support nurses to integrate mental health services into their work.