This Article supports SDG 3 by evaluating alanine transaminase antiviral treatments for hepatitis B virus infection in China. The authors suggest the optimal treatment coverage for both cost-effectiveness and mortality reduction based on their findings

This is a Personal View discussing socioeconomic risk factors for dementia in women in Latin American Countries, with emphasis on gender roles and expectations that can infleuence the onset and prevalence of dementia

The authors explore automatic and early detection methods for Alzheimer’s disease (AD) using deep learning techniques in order to improve the speed and accessibility of current testing methods. They propose a deep transfer learning model as a new approach for accurately detecting categories of Alzheimer's disease. The research serves SDG 3's aim in highlighing and seeking better treatment for AD, an increasingly serious global public health issue.

Tuberculosis is often reported in people with HIV. In this secondary post-hoc analysis of the A5274 REMEMBER clinical trial, the authors identified that people with HIV and moderate-to-severe anaemia had a higher incidence of TB than those with HIV who did not have anaemia. Addressing two key diseeases listed in SDG 3.3 (HIV and TB), the authors call for close monitoring of people with HIV and anaemia.

This study underscores a novel mechanism(s) underlying HIV-1 Tat-mediated ferroptosis and microglial activation involving miR-204–ACSL4 signaling.

SCFA contribute to the glutamate-glutamine shuttle by acting on glutamine synthetase. Long-term SCFA diet alleviates cognitive and spatial memory defeat in APP/PS1 mice. Long-term SCFA diet reduces Aβ deposition and abnormal phosphorylation of tau. SCFA promote astrocyte-neuron metabolic coupling to reduce oxidative damage.

In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.

Background: COVID-19 and the climate crisis have caused unprecedented disruptions across the world. Climate change has affected the mental health and wellbeing of children and adolescent.

Cervical cancer is the fourth most common malignancy in women of reproductive age globally and specially among women living with HIV in low-income and middle -income countries. This Position Paper shows specific challenges and uncertainties on the way to cervical cancer elimination for women living with HIV and highlights the scarcity of evidence for the effect of interventions in this population. The piece calls for the expansion of HPV immunization programmes for women

This article highlights the risks of a polluted environment on our health, especially reproductive health and female fertility.