This Article supports SDG 3 by evaluating the effect on mental health of the Community Wealth Building programme in Preston, UK, whereby the local economy in this economically deprived area was boosted by shifting to local supply chains. Compared with control areas, an improvement was seen in mental health outcomes such as prevalence of depression. The authors suggest that such a model could simultaneously help to advance economic regeneration, improve health and wellbeing, and reduce regional inequalities.