To determine parent based perceptions of a SEND cycle training programme, factors which predict intention to cycle more and ongoing barriers to cycling.

A high plant-based diet index was associated with a lower risk of frailty in older Chinese adults, especially in men and those with healthy lifestyles. Consistently maintaining a high plant-based diet over time significantly reduced the risk of frailty. The protective effects of a plant-based diet against frailty were not observed in women and those unhealthy lifestyles, suggesting gender and lifestyle-specific differences.

This review discusses the critical role of oxidative stress in the pathogenesis of neurological disorders such as stroke and Alzheimer's disease (AD), detailing the mechanisms of reactive oxygen species (ROS) generation in the brain and exploring the potential of antioxidant therapies as therapeutic targets.

Alzheimer disease (AD) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. Autophagy is a cellular cleaning process involved in the degradation of proteins, including proteins directly responsible for amyloid plaques, but its activity is compromised in AD. This study showed that reducing dietary protein intake can reduce mTORC1 activity and amyloid plaque deposition in the brains of male mice with a less aggressive model of Alzheimer's disease, but not in a more aggressive model or in female mice.

Nitric Oxide can act as both protecting and aggravating factor in Alzheimer's Disease. Nitric oxide can be considered as a neurotoxic factor in Alzheimer's Disease. Nitric Oxide induces neuro plasticity, neuroprotection, neurogenesis, long-term potentiation, and myelination. Drugs based on Nitric Oxide have shown promising results in Alzheimer's Disease. Nitric Oxide can via sundry ways ameliorate memory formation.

This Article supports Sustainable Development Goal 3 by showing a positive association between hearing loss without hearing aid use and dementia in adults aged 40-69 years in the UK. The authors analysed all-cause dementia, as well as specific types including Alzheimer's disease. Hearing loss was associated with increased risk of dementia, and using hearing aids was associated with a similar risk of dementia to no hearing loss, suggesting that hearing aid use in people with hearing loss could reduce dementia risk.

The 2022 UN Climate Change Implementation Plan acknowledged the necessity of taking action to address climate change and safeguard water and food security within a human-rights-based approach.1 Low-income and middle-income countries are disproportionately affected by climate change and have less capacity to respond to climate-related impacts such as sea-level rise, extreme weather events, drought, population displacement, and disease.

Richard et al. provide extensive evidence suggesting that treatment with the HIV-1 attachment inhibitor temsavir can have beneficial effects that extend beyond viral neutralization, notably by preventing elimination of uninfected cells and induction of a cytokine burst caused by its soluble viral glycoprotein.

Dolutegravir is the globally recommended first-line therapy for HIV. In this paper researchers assess the effects of dolutegravir roll-out in the country with the highest HIV burden.

Early treatment of HIV is essential for the health of infants living with HIV; this study looks at ways to improve case-finding.