This study shows that the Cognitive Stimulation Therapy program can significantly improve general cognition, communication, and reduce depression in people living with dementia, regardless of the underlying pathology. However, the effects vary by dementia subtype, with some gains maintained long-term in vascular dementia (VaD) but not in Alzheimer, especially regarding narrative abilities and depressive symptoms, highlighting the importance of personalized approaches.

This review emphasizes that integrating amyloid and tau PET imaging with genomics and proteomics significantly advances our understanding of the biological mechanisms underlying Alzheimer’s disease, fostering greater awareness of dementia’s complexity and paving the way for improved diagnosis, prognosis, and personalized care.

In the Han Chinese populations on the Mongolian Plateau, the MTHFR G677A mutation is associated with increased homocysteine levels, which are linked to a higher risk of Alzheimer's disease. This genetic variant highlights the potential impact of folate metabolism on neurodegenerative conditions in this specific population.

This study shows how nurse-led health education improves dementia care by reducing behavioral problems and strengthening caregiver skills. By providing caregivers with lifelong learning and practical knowledge, it also advances quality education.

The review summarizes and discusses the potential role of psilocybin, a psychedelic compound, in altering mechanisms associated with major depression and neurodegenerative diseases. It examines the relationship between adult hippocampal neurogenesis, microglial activity, and their implications for the development of dementia, particularly in the context of major depression as a risk factor.

The emergency department (ED) poses unique challenges and risks to persons living with dementia. A longer ED length of stay is associated with the risk of death, delirium, and medication errors. This article seeks to determine whether ED length of stay differed by dementia status and trends in ED length of stay for persons living with dementia and whether persons living with dementia were at a higher risk for prolonged ED length of stay.

The article explores the role of microglia and neuronal subpopulations in Alzheimer's disease (AD) progression. It reveals that the microglia subpopulation Mic_PTPRG communicates with specific excitatory (ExNeu_PRKN_VIRMA) and inhibitory (InNeu_PRKN_VIRMA) neuronal subpopulations, leading to the upregulation of VIRMA, which inhibits mitophagy and causes neuronal death.

This study aims to assess depression and perception of vocal handicap in individuals with and without early-stage Alzheimer's disease (AD) using a self-report method. Depression is commonly observed in elderly individuals and can significantly impact their quality of life, management of chronic diseases, and daily and instrumental activities. In elderly individuals with AD, the risk of depression is twice as high compared to those without Alzheimer's.

Article discusses the relationship between hypertension and dementia, and the potential utility of antihypertensive medications in reducing the risk of cognitive decline and dementia. It concludes that mid-life hypertension is a risk factor for both vascular dementia and Alzheimer's disease, and that further research is needed to clarify the neuroprotective properties of different antihypertensive drug classes.

Fecal microbiota transplantation (FMT) from young donors can delay aging and improve health outcomes by restoring gut microbiota balance, with potential therapeutic benefits for neurodegenerative diseases like Alzheimer's through the gut–brain axis. However, challenges remain in donor selection and establishing effective transplantation protocols.