Article discusses the relationship between hypertension and dementia, and the potential utility of antihypertensive medications in reducing the risk of cognitive decline and dementia. It concludes that mid-life hypertension is a risk factor for both vascular dementia and Alzheimer's disease, and that further research is needed to clarify the neuroprotective properties of different antihypertensive drug classes.

Fecal microbiota transplantation (FMT) from young donors can delay aging and improve health outcomes by restoring gut microbiota balance, with potential therapeutic benefits for neurodegenerative diseases like Alzheimer's through the gut–brain axis. However, challenges remain in donor selection and establishing effective transplantation protocols.

Neurocognitive dysfunction is common in heart failure (HF), and is independently associated with worse outcomes including mortality, rehospitalization, and reduced quality of life. It is paramount to raise awareness of the neurocognitive consequences in ischemic HF and devise strategies for recognition and prevention as an important target of patient management and personalized decision making that contributes to patient outcomes. This review outlines the current evidence and gaps in our understanding of neurocognitive dysfunction in HF and their implications on selection of revascularization strategies in patients with ischemic HFrEF.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by discussing the role of genetic variants found to affect cholinergic and noncholinergic neurotransmission.

RELX Environmental Challenge 2025: four shortlisted projects to bring safe water and sanitation to communities around the world

The RELX Environmental Challenge 2025 shortlist features four innovative projects that provide sustainable access to safe water and improved sanitation.  The RELX Environmental Challenge prioritises replicable, scalable, sustainable and innovative solutions. They must also have practical applicability and involve local communities and other key stakeholders.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by identifying potential nutraceutical applications of bioactive compounds for prevention and treatment of Alzheimer's Disease.