This study identifies TLR5 as a marker for brain border-associated macrophages (BAMs) in neonatal mice and demonstrates that TLR5 expression on these macrophages enhances their ability to defend against bacterial meningitis by activating immune responses and recruiting innate immune cells. The findings highlight the role of TLR5 in neonatal brain immunity and suggest potential therapeutic strategies for preventing bacterial meningitis in infants.

The results of this study emphasize the importance of considering lifestyle aspects like sleep, physical activity, and social support when creating effective strategies to prevent depression in university students.

This content aligns with Goal 3: Good Health and Goal 9: Industry, Innovation and Infrastructure by discussing the relationship between mental health and the COVID-19 pandemic in children and youth, and the infrastructure in place to address declines in mental health in these populations.

This content aligns with Goal 3: Good Health by demonstrating how advancements in 3D printing (3DP) technology enhance medical service delivery by creating customized prosthetics, implants, and equipment that can significantly improve health outcomes for individuals, particularly para-athletes and those with limb loss. By emphasizing the benefits of personalized medical devices and the potential for improved activities of daily living, the chapter highlights the importance of innovative solutions in healthcare. Additionally, it supports Goal 10: Reduced Inequalities by advocating for accessible and customized technologies that empower para-athletes and individuals with disabilities, promoting equity in sports and medical care and ensuring that all individuals have the opportunity to participate fully in both athletic and everyday activities.

Purpose: Sarcopenia or age-associated muscle loss is common in patients with Alzheimer's disease (AD). We have previously demonstrated the contribution of a leaky gut to sarcopenia in AD.