This study shows how nurse-led health education improves dementia care by reducing behavioral problems and strengthening caregiver skills. By providing caregivers with lifelong learning and practical knowledge, it also advances quality education.

The review summarizes and discusses the potential role of psilocybin, a psychedelic compound, in altering mechanisms associated with major depression and neurodegenerative diseases. It examines the relationship between adult hippocampal neurogenesis, microglial activity, and their implications for the development of dementia, particularly in the context of major depression as a risk factor.

The emergency department (ED) poses unique challenges and risks to persons living with dementia. A longer ED length of stay is associated with the risk of death, delirium, and medication errors. This article seeks to determine whether ED length of stay differed by dementia status and trends in ED length of stay for persons living with dementia and whether persons living with dementia were at a higher risk for prolonged ED length of stay.

The article explores the role of microglia and neuronal subpopulations in Alzheimer's disease (AD) progression. It reveals that the microglia subpopulation Mic_PTPRG communicates with specific excitatory (ExNeu_PRKN_VIRMA) and inhibitory (InNeu_PRKN_VIRMA) neuronal subpopulations, leading to the upregulation of VIRMA, which inhibits mitophagy and causes neuronal death.

This study aims to assess depression and perception of vocal handicap in individuals with and without early-stage Alzheimer's disease (AD) using a self-report method. Depression is commonly observed in elderly individuals and can significantly impact their quality of life, management of chronic diseases, and daily and instrumental activities. In elderly individuals with AD, the risk of depression is twice as high compared to those without Alzheimer's.

Article discusses the relationship between hypertension and dementia, and the potential utility of antihypertensive medications in reducing the risk of cognitive decline and dementia. It concludes that mid-life hypertension is a risk factor for both vascular dementia and Alzheimer's disease, and that further research is needed to clarify the neuroprotective properties of different antihypertensive drug classes.

Fecal microbiota transplantation (FMT) from young donors can delay aging and improve health outcomes by restoring gut microbiota balance, with potential therapeutic benefits for neurodegenerative diseases like Alzheimer's through the gut–brain axis. However, challenges remain in donor selection and establishing effective transplantation protocols.

Neurocognitive dysfunction is common in heart failure (HF), and is independently associated with worse outcomes including mortality, rehospitalization, and reduced quality of life. It is paramount to raise awareness of the neurocognitive consequences in ischemic HF and devise strategies for recognition and prevention as an important target of patient management and personalized decision making that contributes to patient outcomes. This review outlines the current evidence and gaps in our understanding of neurocognitive dysfunction in HF and their implications on selection of revascularization strategies in patients with ischemic HFrEF.

This study seeks to identify what matters to older adults (60 years and older) presenting to the emergency department (ED) and the challenges or concerns they identify related to medication, mobility, and mentation to inform how the 4Ms framework could improve care of older adults in the ED setting.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by exploring a novel area of research exploring the link between vascular disease and Alzheimer's Disease.