This paper conducts a scoping review of research on the involvement of the glymphatic system in Alzheimer's disease-related sleep disturbances, finding that sleep disturbances impact protein aggregation and toxicity, glymphatic sequelae in sleep-disordered breathing, circadian dysregulation, and potential interventions, thus providing insight into the role of sleep disturbances in AD pathogenesis through glymphatic disruption.

In Alzheimer's disease research, cerebrospinal fluid (CSF) biomarkers Amyloid beta (Aβ), Tau, and pTau are well-validated, and this study demonstrates that a Z-score based harmonization approach can effectively standardize CSF and amyloid imaging data across multiple cohorts, providing consistent biomarker cut-offs and comparable GWAS results to traditional methods, without introducing spurious findings.

This article reviews recent research on the pathogenesis of Alzheimer's disease, emphasizing the role of the gut-brain axis and examining clinical and preclinical studies on fermented foods, which have shown promising effects on amyloid-β metabolism, inflammation, and cognitive impairment, suggesting potential for new therapeutic and preventive measures for Alzheimer's disease.

Comprehensive review: summary of genetic factors, relation between gut microbiome and AD, overview of latest drugs, influence of lifestyle and diet, and pathophysiology of AD development.

This study finds that pine nut peptide-zinc chelate improves Alzheimer's Disease (AD) in various ways which include (1) improving learning, memory, brain health, and gut balance in mice, and (2) treating cholinergic system changes, boosting cerebral antioxidants, and altering gut microbiota. Pine nut peptide-zinc chelate holds potential for AD therapy, requiring deeper mechanistic investigation.

The “contour smoothing” fractal analysis method can effectively examine cerebral hemispheres to detect and quantify age-related atrophic changes associated with normal or pathological aging. This method holds promise for clinical application in diagnosing neurodegenerative disorders, such as Alzheimer’s disease.

This review is to provide a comprehensive overview of recent developments in deep learning methodologies applied to brain MRI images for the classification of various stages of Alzheimer's disease, with a particular emphasis on early diagnosis. Furthermore, this review underscores the limitations of current research, discussing potential challenges and future research directions in this dynamic field.

The study reveals that damage to the blood-brain barrier increases the proportion of microglia, a type of brain cell, which contributes to the progression of aging and Alzheimer's disease. It also identifies ten different functional types of microglia and underscores the significance of certain signalling pathways in communication between cells.

In this review, we summarized the potential therapeutic effects and related mechanisms of Panax ginseng in treating AD and VaD to provide some examples for further studies.

This study aimed to investigate the amelioration effects of preventive TEAS treatment (P-TEAS) on cognitive impairment and oxidative stress in AD model rats.