Lifestyle factors, including physical activity, dietary patterns, sleep, stress response, social connections, and use of risky substances, are increasingly recognized as predictors of cardiovascular disease (CVD) and cardiovascular health, with significant overlap between the American Heart Association's Life's Essential 8 guidelines and the 6 pillars of Lifestyle Medicine (LM). Assessing and addressing lifestyle factors have a foundational role in the prevention and management of cardiovascular disease and improving cardiovascular health.