This content aligns with Goal 3: Good Health and Wellbeing as well as Goal 10: Reducing Inequalities by reviewing the data on clinical and epidemiological predictors of antidepressant response, or predictors of treatment-resistant depression and discussing the possible prognostic value of clinical features, like severity, chronicity, subtypes of depression, comorbidities, history of trauma, and epidemiological features like gender, age, sociodemographic status.