The results of this study, which looks at the emissions and performance of the ICE fueled by ethanol, are in line with SDGs 7 and 13. Regarding optimization and prediction, the distinctive combination of ANN and RSM encourages sustainable industrialization, more conscientious consumption, and more ethical production patterns. All these are crucial components of SDGs 9 and 12. To make refined decisions and achieve improved performance and emissions, this research can benefit engine producers and researchers. This alliance between scholars and industry stakeholders supports SDG 17 (Partnerships for the Goals), which also encourages knowledge-sharing to advance the SDGs as a whole.