The article discusses the critical role of the mitochondrial contact site and cristae organizing system (MICOS) complex in the pathogenesis of Alzheimer's disease (AD). It highlights how MICOS abnormalities, including subunit dysfunction and interactions with disease-associated proteins, to hallmark AD pathologies such as amyloid-β accumulation, neurofibrillary tangle formation, and neuronal apoptosis. The article suggests that targeting MICOS subunits with pharmacological interventions may provide novel therapeutic insights for AD treatment.

This study indicates neurofibrillary tangles(NFT) level detection in patients with extracranial carotid atherosclerotic disease (ECAD) could enable earlier identification of those at high risk for developing Alzheimer's and other dementias, sometimes decades before symptoms. As blood-based assays to quantify NFT's are more clinically available, this could guide more targeted prevention and early treatment strategies for patients.

This study examines how multilingual elementary students use concept maps in an after-school science club to communicate scientific ideas, revealing that they position themselves as competent learners by making flexible language choices and incorporating personal experiences.

This study examines the impact of living conditions on cognitive function in older adults in China, and explores the role of plant-based dietary patterns in mitigating the negative effects of poor living conditions. The key finding is that living in fair or poor conditions was associated with an increased risk of developing cognitive impairment, and this association was more pronounced in the "Low-stable-decreasing PDI" group compared to the "High-rapid-decreasing PDI" group.

Background: Earlier evidence indicated that metabolic and bariatric surgery (MBS) may adversely affect neonatal outcomes among patients conceiving soon after MBS, but recent studies demonstrated co

The menopausal transition, defined by the cessation of menstruation due to declining ovarian follicular function, results in a marked decrease in endogenous estrogen levels.

This article examines the associations between adverse childhood experiences (ACEs) and adverse adulthood experiences (AAEs) with depressive and anxiety symptoms among rural left-behind women in China.