Background: Ovarian cancer presents with non-specific symptoms that make early diagnosis challenging and the prognosis poor. Ovarian and endometrial cancers exhibit similar genomic mutations and biomarker profiles. Endogenous volatile organic compounds (VOCs) are products of metabolic activity. In cancer, metabolites increase due to tumour necrosis, leading to cancer-specific VOC patterns. The aim of this study was to evaluate VOC analyses in plasma as diagnostic tests for early diagnosis of ovarian and endometrial cancer.

Metalloproteins have evolved through the selective, strong, and precise interactions between metal ions and polypeptides. The coordination of metal ions to amino acid side chains is therefore a fundamental prerequisite for designing metalloproteins. Here, we present Metal-Installer, a user-friendly in silico tool that proposes probable mutation sites for metal ligation.

We introduce a new approach to defect engineering in Zr-based metal-organic frameworks (Zr-MOFs), aiming to reduce Zr site valency while preserving high node connectivity. Using a rapid heat treatment (RHT) in humid air, oxygen vacancies (O-vacancies) were created in Dresden University of Technology (DUT)-67 through cluster dehydration. Unlike conventional defect engineering, aimed at creating missing-linker defects, this method breaks intra-cluster Zr-μ3O–Zr bonds, generating coordinatively unsaturated Zr (Zrcus) sites.

The menopausal transition, defined by the cessation of menstruation due to declining ovarian follicular function, results in a marked decrease in endogenous estrogen levels. This phase is associated with significant metabolic changes and a shift towards a more atherogenic lipid profile. Specifically, there are increases in total cholesterol, low-density lipoprotein cholesterol, and triglycerides and unfavorable alterations in high-density lipoprotein cholesterol and lipoprotein(a) levels.

Artificial intelligence (AI) is making remarkable strides in the field of oncology. The potential is humongous, but the perils are understated. From the perspective of gynecologic oncologists from India, we urge everyone to take a cautionary look at the rapid AI evolution in oncology.

Objectives To describe the demographic and social identities of participants in contemporary Canadian randomized clinical trials (RCTs). Study Design and Setting A meta-epidemiologic study included published reports of phase 2 and 3 RCTs that exclusively recruited adults living in Canada and were registered on ClinicalTrials.gov between January 1, 2010, and December 31, 2019. Study design and participant demographics were abstracted from eligible articles in duplicate using frameworks for understanding participant diversity such as PROGRESS-PLUS.

This study investigates how women volunteers in urban China perform identity work within the gendered structures of community volunteering. While community volunteerism is widely perceived as feminized, informal, and devalued labor, women actively construct, negotiate, and sometimes challenge the meanings of volunteer roles. Drawing on three months of ethnographic fieldwork in two women-led community volunteer groups in Beijing, this research shows that women navigate gendered expectations by building civic networks, formalizing their practices, and leveraging political identities.

This study analyzes hydrogen production using photoelectrochemical (PEC) water splitting methods for Ga-doped ZnO electrodes coated on stainless steel. Physical electrochemistry, electrochemical impedance, hydrogen production, X-ray diffraction (XRD), and scanning electron microscopy (SEM) analyses are performed on uncoated, undoped ZnO-coated, and Ga-doped ZnO-coated electrodes. The parameters of the best-coated electrode obtained by chronoamperometry (CA) analysis are as follows: the electrode is immersed in a dip-coating bath for 4 s, is coated five times, and has a doping ratio of 1%.