A fundamental shift in how cancer research is conducted and how cancer care is delivered in the United States is required in order to deliver on the Cancer Moonshot initiative, according to a major new report called The Lancet Oncology Commission: Future Research Priorities in the USA. Authored by over 50 leading oncologists, including members of leading US cancer organizations, the report sets out 13 key priority areas, each with measurable goals, to focus the $2 billion of funding released to the National Cancer Institute (NCI) as part of the 21st Century Cures Act.