Essential Guide to Neurodegenerative Disorders: Chapter 1 - The biochemical pathways of Alzheimer's disease

One of the common neurodegenerative disorders, Alzheimer's disease (AD) is associated with extracellular plaque formation in the hippocampus and amyloid-β (Aβ) peptide misfolding and aggregation. There currently needs to be an effective treatment for this disease, as there is no clear understanding of how it develops, what causes it, or how it works. However, previous studies have demonstrated the role of Tau, glial, and amyloid (A) in the pathogenesis of AD. As a result, this chapter gives an overview of these pathways and how important they are to AD development.