The pomegranate (Punica granatum), often celebrated as a symbol of health and vitality in various cultures, has long been revered for its succulent seeds and juice, which are packed with antioxidants, vitamins, and minerals. However, an often-overlooked aspect of this remarkable fruit is its peel, which has been traditionally discarded in culinary practices. Recent scientific investigations are beginning to shed light on the impressive array of health benefits associated with pomegranate peel (PP), revealing it to be a treasure trove of bioactive compounds, the rich phytochemical profile of the peel, including polyphenols, flavonoids, and tannins, positions it as a potent natural remedy for various ailments that can contribute significantly to human health. Biowaste management is a significant global challenge that affects both the environment and public health, while also imposing considerable economic burdens. In 2018 food waste disposal fees in the United States reached approximately $1.9 billion. Biocascade actively promotes the full utilization of biowaste, converting every component into valuable products in line with the principles of a circular economy, where all food resources are effectively recycled. The valorization of PP biowaste not only alleviates its environmental and economic impacts but also offers a promising avenue for the development of innovative and enhanced nutraceuticals. In this chapter, we will explore the numerous health-promoting properties of PP, which include its antioxidant, antiinflammatory, and antimicrobial effects. Furthermore, emerging research highlights its potential in managing chronic diseases, such as diabetes, cardiovascular disorders, and certain types of cancer. Additionally, we will delve into traditional uses of PP in various cultures and its incorporation into modern health practices, including the development of supplements, herbal remedies, and natural skincare products. Through a comprehensive examination of both historical and contemporary perspectives, this chapter aims to illuminate the significant role that PP can play in fostering better health and well-being. By the conclusion of this chapter, readers will not only appreciate the pomegranate in its entirety but also recognize the peel as a valuable resource that deserves a place in our diets and wellness routines. Join us on this journey to unlock the potential of PP and uncover its myriad of health benefits.