This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.

This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.

This study examined how air pollution exposure affects asthma treatment effectiveness in Black children by reanalyzing data from the AsthmaNet BARD clinical trial. The researchers found that children with lower nitrogen dioxide (NO2) exposure had significantly better lung function improvements when treated with high-dose inhaled corticosteroids plus long-acting ?-agonists compared to children with higher NO2 exposure. The findings suggest that residential air pollution exposure, particularly NO2, may reduce the effectiveness of standard asthma treatments in Black children, highlighting the need to consider environmental factors in asthma management strategies.

This study investigated how host genetics and early-life environmental exposures influence the infant gut microbiota during the first year of life and its association with childhood asthma and allergic diseases by age 5 years. The researchers found that specific gut microbial changes and network clusters were associated with increased or decreased risk of asthma, wheeze, atopic dermatitis, and food/inhalant sensitization, with some associations being sex-specific

The study demonstrates that adopting more climate-friendly diets, which typically involve reduced animal-based food consumption and lower absolute micronutrient intakes, does not substantially increase the risk of micronutrient deficiencies for most nutrients. These findings underscore the importance of assessing both dietary intake and actual nutrient status when evaluating the nutritional consequences of sustainable eating patterns, supporting the potential health and environmental benefits of shifting toward climate-friendly diets.

Low-income citizens show the highest support for food labeling and educational campaigns, viewing them as effective and less intrusive, while taxation and checkout prompts are least accepted due to perceived invasiveness. Policy support is strongly influenced by perceived effectiveness, intrusiveness, and individuals’ existing behaviors, suggesting tailored approaches are needed to improve acceptance and impact.