There is an urgent need to endorse a protective therapy for ALS patients. Possible treatments might be based on the underlying molecular pathophysiology. Some of the ALS dysregulated routes could be targeted by a single hit in NRF2. NRF2 emerged as a druggable target in preclinical and clinical trials for ALS.
Given their carbon emissions, pharmaceutical companies must intensify their efforts and play an active role in addressing climate change.
This study demonstrates that systems science provides positive implementation approaches to design and translates nutrition behaviors and knowledge into practice.
This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. This article investigates whether changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.
Reelin deficiency when combined with AD risk-factors produced consistent impairments in spatial memory tasks. Furthermore, the results further implicate Reelin’s importance in both HF homeostasis and AD pathogenesis.
An article on the pathology of Alzheimer's disease, in the context of SDG 3, focusing specifically on the potential use of an anti-cancer drug to modulate cerebrovascular angiogenesis as an alternative therapeutic strategy.
An article on the detrimental effects of COVID-19 isolation on the cognitive and mental health of people with dementia, in the context of SDGs 3 and 10, highlighting the need for guidance that balances infection control measures with principles of non-maleficence to appropriately care for this patient group.
Hypotheses for the pathogenesis of Alzheimer’s disease (AD) are described in this paper. The review is intended to be a basic and encyclopedic short insight into metals in AD and discusses the advances in chelation strategies and developments adopted in the treatment of the disease.
