Every year, 10 million people develop dementia, most commonly Alzheimer's disease (AD), and despite limited therapies and no prevention for cognitive decline, this review offers a neuroimmunological perspective on AD progression, focusing on the role of the NLRP3 inflammasome, its brain triggers, and the potential impact of various NLRP3 inhibitors currently under investigation in preclinical and clinical trials.
The study discusses the latest developments in Alzheimer’s disease treatment, with a focus on monoclonal antibodies and aptamers. It covers the current state of therapies, recent drug approvals, and future perspectives on immunotherapeutic strategies.
This article discusses the impact of methionine oxidation on clusterin function in Alzheimer's disease, highlighting the elevated levels of MetO-clusterin in human and mouse brains affected by the disease, and how this oxidation compromises clusterin's chaperone function, potentially exacerbating beta-amyloid toxicity in Alzheimer's pathology.
This Article supports SDG 3 by assessing the effectiveness of a hepatitis B model of care in Australia, suggesting that the model, involving primary health care, could be rolled out nationally or internationally. The authors suggest that the model could have positive implications particularly for low-income and middle-income countries.
This Article supports SDG3 by evaluating the cost-effectiveness of integrating simplified hepatitis C virus testing with HIV PrEP treatment among men who have sex with men.
This Article supports SDG 3 by evaluating a hepatitis B screening programme in which members of the West African community in the Bronx were offered hepatitis B testing when they attended a blood pressure clinic visit following an educational intervention about hypertension. Almost all participants accepted to have hepatitis B screening, showing the effectiveness of its being linked to blood pressure testing.
This Article supports SDG 4 by documenting significant improvements in fibrosis-based liver disease burden with direct-acting antivirals, among a cohort of patients with chronic hepatitis C.
This study supports SDG 3 by analyzing expenditures on hepatitis B treatments, promoting better health resource management.
The aim of the paper is to understand the culture around birth and indigenous people. This study aimed to understand First Nations women’s perceptions of placenta burial and a dedicated placenta garden in supporting connection to their culture.
Although Indigenous Australians critically ill with sepsis have similar short and long-term mortality rates, they present to hospital, die in-hospital, and die post-discharge significantly younger. Unique cohort characteristics may explain these outcomes, and assist clinicians, researchers and policy-makers in targeting interventions to these characteristics to best reduce the burden of sepsis in this cohort and improve their healthcare outcomes.
