Health and population

Health and population dynamics are intertwined, embodying an intricate relationship with significant implications on the Sustainable Development Goals (SDGs). Health is fundamentally at the center of these 17 global goals, aimed to transform the world by 2030. Specifically, Goal 3 endeavors to "Ensure healthy lives and promote well-being for all at all ages." It acknowledges that health is pivotal to human life quality, social cohesion, and sustainable development. Inextricably linked to this are the complexities of population dynamics, including growth rates, age structure, fertility and mortality rates, and migration patterns.

With the world's population projected to exceed 9.7 billion by 2050, the pressure on health systems will undoubtedly escalate. The demographic transition, with an aging population and an increasing prevalence of non-communicable diseases, poses new challenges for health systems globally. Additionally, areas with high fertility rates often overlap with extreme poverty, resulting in heightened health risks, including higher maternal and child mortality rates, malnutrition, and infectious diseases.

Moreover, rapid urbanization and migration present both opportunities and threats to health. While urban areas may provide better access to healthcare, they also harbor risks of disease transmission, air and water pollution, and social determinants of health like inadequate housing and social inequality. Simultaneously, migrants often face disproportionate health risks due to unstable living conditions, exploitation, and limited access to healthcare services.

Achieving the SDGs will necessitate comprehensive approaches that consider the intricate interplay of health and population dynamics. It means strengthening health systems, promoting universal health coverage, and addressing social determinants of health. It also implies crafting policies that recognize demographic realities and foster an environment conducive to sustainable development. Only by understanding and harnessing these dynamics can the world meaningfully progress towards realizing the SDGs, ensuring healthy lives and well-being for all.

A systematic review and meta-analysis on the prevalence and risk factors of frailty in people experiencing homelessness (PEH).�

This article systematically summarizes the neuroprotective effects and mechanisms of ginsenosides Rg1, Rb1, and rare ginsenosides against Parkinson's disease (PD) and Alzheimer's disease (AD). The key findings indicate that ginsenosides exert their beneficial effects by modulating various signaling pathways related to inflammation, oxidative stress, apoptosis, and autophagy.

This study analyzes how healthcare, health, and social factors contribute to high out-of-pocket health expenditures (OOPE) among informally employed Cambodian households without prepayment schemes, finding that healthcare-related factors are the largest drivers of financial hardship. The authors recommend expanding prepayment schemes focused on comprehensive outpatient care, essential medications, and higher-level services, while also addressing noncommunicable diseases and injuries to improve financial protection.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by discussing the understudied impacts of the gut microbiome and chronic inflammation that may contribute to neurodegeneration.
This review highlights how nurse practitioners can strengthen Alzheimer’s disease care by supporting earlier diagnosis and access to treatment, which is essential for maintaining quality of life. Expanding their role helps reduce barriers in the healthcare system, ensuring people with Alzheimer’s receive timely care that promotes better health and well-being.
The article discusses the potential of artificial intelligence (AI) in revolutionizing drug discovery for Alzheimer's disease (AD) and delirium. It explores how AI can facilitate target identification, small molecule and protein-based drug design, and optimization of pharmacokinetic properties to address the challenges in developing effective treatments for these two brain diseases.
The article suggest that beta-amyloid protein (Aβ) has a significant indirect effect on neurogranin (Ng) through key synaptic mediators such as SYT1 and GAP43 during the preclinical stages of Alzheimer’s disease (AD). These findings highlight the crucial role of SYT1 and GAP43 in mediating beta-amyloid-induced synaptic dysfunction, offering potential early biomarkers and therapeutic targets for AD progression.
The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.

The article provides a comprehensive consensus on optimal exercise recommendations for enhancing healthy longevity in older adults.�

This article investigates factors contributing to longer wait times in the Emergency Department for Non-Hispanic Black and Hispanic patients.

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