Elsevier,
SLAS Discovery, Volume 28, June 2023
In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
Elsevier, The Lancet Regional Health - Southeast Asia, Volume 13, June 2023
Background: COVID-19 and the climate crisis have caused unprecedented disruptions across the world. Climate change has affected the mental health and wellbeing of children and adolescent. Young people with a mental illness and without social support are at an increased risk of climate change induced mental ill-health. COVID-19 resulted in a marked increase of psychological distress. Increase in depression, anxiety and insomnia have increased due to the upheavals that people were experiencing including loss of livelihood and breaking of social bonds.
Elsevier,
Nano Energy, Volume 110, 1 June 2023
Fossil fuel utilization as an energy resource is the main cause of CO2 emission; therefore, a new energy economic concept is required to achieve carbon neutrality to mitigate climate change impacts. Here, the authors propose a green-alcohol (green-ol) economy wherein green-ol, a major chemical used in CO2 recycling, can serve as fuel for land (e.g. ethanol) and air transport (e.g. butanol), and as a liquid organic hydrogen carrier (LOHC, e.g. methanol) for green hydrogen.
Elsevier, One Earth, Volume 6, 16 June 2023
The role of migration as one potential adaptation to climate change is increasingly recognized, but little is known about whether migration constitutes successful adaptation, under what conditions, and for whom. Based on a review of emerging migration science, we propose that migration is a successful adaptation to climate change if it increases well-being, reduces inequality, and promotes sustainability.
Elsevier,
The Lancet HIV, Volume 10, June 2023
Cervical cancer is the fourth most common malignancy in women of reproductive age globally and specially among women living with HIV in low-income and middle -income countries. This Position Paper shows specific challenges and uncertainties on the way to cervical cancer elimination for women living with HIV and highlights the scarcity of evidence for the effect of interventions in this population. The piece calls for the expansion of HPV immunization programmes for women
Elsevier,
Geoderma Regional, Volume 33, June 2023
Castellanos-Barliza and León-Peláez 2023 investigated the recovery of physical-chemical and biological properties of Technosols in a chronosequence of drylands (over 7,10 and 21 years) in the El Cerrejón coal mine in Colombia. Their results showed significant improvements in soil properties, especially near the surface, with notable increases in soil N content and P solution after 7 years. Enhanced vegetation development over time contributed to higher soil organic matter, indicating successful rehabilitation and positive impacts of the restoration strategy in degraded mine spoils.
