Animal models are used with increasing numbers in the late LO phase and particularly in the candidate selection phase for pharmacokinetic/pharmacodynamic (PK/PD) and efficacy, and then also used in regulatory required safety studies. Therefore, there are opportunities throughout the drug discovery process to incorporate more translationally predictive cellular models, or CIVMs, to both reduce animal use aligned to our 3Rs commitment (replacement, reduction, and refinement) and provide data that better translate to the clinic, which ultimately results in better medicines for patients.
Background: Research has revealed that survivors of childhood sexual abuse (CSA) have elevated sexual dysfunction and distress.
Background: Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR).
Background: Coronovirus disease 2019 (COVID-19) first broke out in Wuhan, Hubei Province, China, in 2019, and now it spreads in more than 100 countries around the world.
Background: Stay-at-home orders (lockdowns) have been deployed globally to control COVID-19 transmission, and might impair economic conditions and mental health, and exacerbate risk of food insecurity
Background: Stay-at-home orders (lockdowns) have been deployed globally to control COVID-19 transmission, and might impair economic conditions and mental health, and exacerbate risk of food insecurity
Purpose: The purpose of this study is to assess the current status of gender disparities in academic radiation oncology departments in the United States and the associated factors.
This study explored an established primary care–based dementia pathway in New Zealand (NZ) and nurse practitioner dementia diagnosis and care in 1 small United States state that has adopted a value-ba
It has recently been proposed that short-term memory (STM) binding deficits might be an important feature of Alzheimer's disease (AD), providing a potential avenue for earlier detection of this disord
