The lung is a crucial immune organ continuously exposed to the external environment. Genetic defects that impair immune function, called inborn errors of immunity (IEI), often have lung disease as the initial and/or primary manifestation. Common types of lung disease seen in IEI include infectious complications and a diverse group of diffuse interstitial lung diseases.
Treatment with tenofovir disoproxil fumarate (TDF) was found to be effective in reducing the occurrence of liver cancer and disease progression in patients with chronic hepatitis B. The treatment also achieved significant viral suppression and improvement in liver fibrosis. This offers hope for individuals with chronic hepatitis B who are at risk of developing liver cancer.
Several studies of adult-onset multiple sclerosis (AOMS) patients have demonstrated that spinal cord volume loss is associated with disease progression and clinical disability; however, complementary studies of young patients with pediatric-onset multiple sclerosis (POMS) are lacking. In the context of SDG Goal 3, this retrospective study aimed to assess spinal cord volume in POMS patients compared with that in healthy controls.
People with any disabilities accounted for a quarter of total deaths. People with disabilities had higher average ages and poor economic conditions. All disability types presented higher mortality rates and lower life expectancy. The major causes of death differed according to the type of disability.
Recommends ways to maximise potential of autonomous vehicles to improve accessibility for disabled persons.
This Review supports Sustainable Development Goal 3 by summarising human studies on the association between brain and visceral white adipose tissue, and defines their interaction and underlying mechanisms on the basis of animal and cell studies.
This Personal View supports SDG 3 by explaining how plastic waste can facilitate the proliferation and propogation of infectious diseases, including arthropod-borne and water-borne diseases, among its other negative effects on the environment
This Article supports SDG 3 and 7 by showing that air pollution exposure increases the risk of almost all phases of cardiometabolic multimorbidity progression.
This Article supports SDG 3 by assessing the safety and efficacy profile of abacavir used in first, second, or subsequent lines of treatment for infants, children, and adolescents living with HIV to inform 2021 WHO paediatric ART recommendations.
This study uses targeted plasma proteomics to show the upregulation of inflammation in people living with HIV.
