This study presents an optimized method for isolating specific neuronal and glial cell populations and extracellular vesicles (EVs) from postmortem Alzheimer's disease (AD) cortical samples, demonstrating the feasibility of using a single cryopreserved brain sample to obtain RNA-seq and protein-level data, thereby enhancing understanding of neuron/glial interactions and disease progression.
Neurological disorders affect approximately one billion people worldwide, with significant disability and mortality impacts, and this review explores how Heparan sulfate proteoglycans (HSPGs) promote Tau fibril formation and tangles in Alzheimer's disease, and the potential role of tunnelling nanotubes (TNTs) in the intercellular transport of Tau and Amyloid β proteins, suggesting that HSPGs may influence TNT formation in neurodegenerative conditions.
This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
This article links to the United Nations Sustainable Development Goals (SDGs) by addressing Goal 3 (Good Health and Well-Being) and Goal 13 (Climate Action), as it highlights the significant greenhouse gas emissions associated with radiotherapy, a critical component of cancer treatment. By proposing strategies to reduce the environmental impact of oncology care through sustainable practices and treatment modifications, the study emphasizes the importance of integrating health care with climate action efforts to promote both patient well-being and environmental sustainability.
The effect of temperature on language complexity: Evidence from seven million parliamentary speeches
iScience, Volume 27, 21 June 2024
In this study, the authors find that warmer temperatures to reduce language complexity of politicians.
This study is a comprehensive assessment of the effects of climate change mitigation and pollution policies in China, providing policy recommendations.
The article underscores the need to reform the health claim evaluation process for foods by adopting a holistic approach that integrates multiple nutritional and contaminant attributes. This approach should involve cumulative risk assessment and risk-benefit analysis to provide a more accurate picture of food's health impacts. Such reforms align with global sustainability goals and would help address the complexities of modern food systems, ultimately promoting better health outcomes and environmental stewardship.
This article ties into SDG3 by examining the relation between air pollution exposure and cardiovascular health especially on particular subpopulations, e.g. younger people, women, residents of rural areas and those with lower income.
This review article summarizes the current evidence for culturally adapted cardiac rehabilitation programming for Indigenous patients, including community engagement. strategies to improve education on cardiovascular risk-factor optimization and to promote guideline-based exercise and diet programs through an Indigenous perspective.
