Estimation of the value-based price of a blood test for Alzheimer's disease pathology in primary and specialty care in the U.S

Elsevier,

Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The article estimates the value-based price of a blood test for Alzheimer's disease pathology, finding it would be $290-$1150 in primary care and $450-$1950 in specialty care, projecting substantial cost savings.
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Health and population; Health and wellbeing, North America

Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy

Elsevier,

Journal of Pharmacology and Experimental Therapeutics, Volume 392, August 2025
This review discusses the dual role of amyloid-beta (Aβ) in Alzheimer's disease (AD). While Aβ accumulation is a hallmark of AD pathology, soluble Aβ also plays a neuroprotective role in regulating synaptic plasticity and memory. The review explores the potential of anti-Aβ immunotherapy as a treatment strategy, highlighting the need to balance targeting toxic Aβ species while preserving the physiological functions of Aβ.`
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Health and wellbeing; Health and population, Global

Detoxification and age-related neurodegenerative diseases: Correlation and therapeutic potential

Elsevier,

Pharmacological Research, Volume 218, August 2025
The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.
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Health and population; Health and wellbeing, Global

AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy

Elsevier,

Pharmacological Research, Volume 218, August 2025
This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.
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Health and population; Health and wellbeing, Global

Gray matter and white matter functional connectivity changes induced by rTMS concurrent with cognitive training in Alzheimer's disease

Elsevier,

Brain Research Bulletin, Volume 228, August 2025
This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.
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Health and wellbeing; Health and population, Global

Heavy Metal Toxicity and Neurodegeneration: Chapter 12 - Heavy metals and Alzheimer’s disease: a review

Elsevier,

Heavy Metal Toxicity and Neurodegeneration, 2025, pp 225-230

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by considering the role heavy metals such as lead, mercury, and cadmium can play in Alzheimer's Disease.

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Health and population; Health and wellbeing, Global

Balancing Environmental Sustainability and Nutrition: Dietary Climate Impact in Relation to Micronutrient Intake and Status in a Swedish Cohort

Elsevier,

Current Developments in Nutrition, Volume 9, August 2025
The study demonstrates that adopting more climate-friendly diets, which typically involve reduced animal-based food consumption and lower absolute micronutrient intakes, does not substantially increase the risk of micronutrient deficiencies for most nutrients. These findings underscore the importance of assessing both dietary intake and actual nutrient status when evaluating the nutritional consequences of sustainable eating patterns, supporting the potential health and environmental benefits of shifting toward climate-friendly diets.
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Health and wellbeing, Global

Low-income citizens’ evaluation of policy interventions to promote healthy food choices

Elsevier,

Food Policy, Volume 135, August 2025
Low-income citizens show the highest support for food labeling and educational campaigns, viewing them as effective and less intrusive, while taxation and checkout prompts are least accepted due to perceived invasiveness. Policy support is strongly influenced by perceived effectiveness, intrusiveness, and individuals’ existing behaviors, suggesting tailored approaches are needed to improve acceptance and impact.
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Global

Neural Interfaces – Chapter 17: Responsible neural technology development: ethical issues and challenges

Elsevier,

Neural Interfaces, 2025, pp 245-260

This chapter explores ethical challenges in the research, development, and commercialization of neural interfaces, aligning with SDG 3 (Good Health and Well-being) by ensuring safe and responsible innovation in neurotechnology, SDG 9 (Industry, Innovation, and Infrastructure) through fostering ethical advancement in cutting-edge technologies, and SDG 10 (Reduced Inequalities) by addressing issues of distributive justice and equitable access to emerging neurotechnologies.

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Diversity and inclusion; Health and wellbeing; Health and population, Global

Ceria nanocluster-based therapy for Alzheimer’s disease through the modulation of activated microglia and attenuation of amyloid-β deposition

Elsevier,

Cell Biomaterials, Available online 6 August 2025, 100158

Ceria nanoclusters, with their ultra-small particle size and and targeted peptides, provides substantial penetration of the blood drain barrier for rapid and susptained relief from neuroinflammation.

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Health and wellbeing, Global

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