Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

Training interventions with psychodrama for formal caregivers of those with dementia
PLCγ2 is genetically linked to Alzheimer’s disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.
Elsevier,

Journal of Trace Elements in Medicine and Biology, Volume 79, September 2023

The role of estrogen and ferroptosis in Alzheimer's disease is known. Ginseng has estrogen-like effects as well as a regulatory role in Alzheimer's disease and iron metabolism and this paper discusses for the frist time the link between ginseng, ferroptosis, and Alzheimer's disease.
Elsevier,

The Lancet Global Health, Volume 11, September 2023

This Comment article supports SDG 3, 6, and 16 by referencing the damage to crucial water and sanitation infrastructure due to the armed conflict in Sudan, thus increasing the likelihood of diarrhoeal disease.
Elsevier,

Metalloenzymes
From Bench to Bedside
2024, Pages 23-34

This content aligns with Goal 3: Good Health and Wellbeing by discussing the mechanism of action and the differences among the different classes of RTs (HIV-1, Tyr3, and TERT) which encompass the three main classes of RTs: retroviruses, retrotransposons, and telomerases, respectively.
This study supports SDG 3 by showing that although people living with HIV in South Africa predominantly have a well controlled condition, there is a high burden of unmet health needs for people living with hypertension and diabetes.
SDG 3.3 is to end the AIDs epidemic, this study shows that of 793,902 people with HIV in Kenya included in the study >25% had low level viraemia, which is associate with a higher risk of virological failure. By defining virological supression as
Elsevier,

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, Volume 271, September 2023

OKA is a potent neurotoxin and has a profound effect on cognitive dysfunction in Zebrafish. 4D and 10D OKA treated zebrafish show significant changes in gene expressions related to neuroinflammation. OKA exposed zebrafish display a substantial number of proteins that are involved in contributing to AD pathology. OKA-induced AD in zebrafish model can be used as a screening tool to explore further underlying possible mechanisms.
Climate change is one of several drivers of recurrent outbreaks and geographical range expansion of infectious diseases in Europe. We propose a framework for the co-production of policy-relevant indicators and decision-support tools that track past, present, and future climate-induced disease risks across hazard, exposure, and vulnerability domains at the animal, human, and environmental interface.
This article advances SDG # 3, 4, 8, 10 and 13 by compiling evidence showing that climate change and its various consequences can adversely affect brain development in the fetal through the early childhood stages. Long-term consequences on health, education and economies are significant. T

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