This study presents an optimized method for isolating specific neuronal and glial cell populations and extracellular vesicles (EVs) from postmortem Alzheimer's disease (AD) cortical samples, demonstrating the feasibility of using a single cryopreserved brain sample to obtain RNA-seq and protein-level data, thereby enhancing understanding of neuron/glial interactions and disease progression.
Neurological disorders affect approximately one billion people worldwide, with significant disability and mortality impacts, and this review explores how Heparan sulfate proteoglycans (HSPGs) promote Tau fibril formation and tangles in Alzheimer's disease, and the potential role of tunnelling nanotubes (TNTs) in the intercellular transport of Tau and Amyloid β proteins, suggesting that HSPGs may influence TNT formation in neurodegenerative conditions.
This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
Elsevier's 2024 Gender Equality Study Reveals 20 Years Of Progress, But Challenges Remain For Women in Research And Innovation
Until now, the absence of data on global building floorspace has impeded the measurement of building carbon intensity (carbon emissions per floorspace) and the identification of ways to achieve carbon neutrality for buildings. For this study, we develop a global building stock model (GLOBUS) to fill that data gap.
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
This research identifies optimal passive retrofitting methods, such as adding insulation, to enhance the resilience of residential buildings and protect vulnerable communities from the safety risks posed by climate change-driven extreme weather events. By increasing he time a building maintains a safe temperature without external power, this approach helps societies adapt to an already warming world while reducing the energy demand that contributes to further temperature increase.
This research demonstrates how the engineering concept of dynamic similitude can be successfully applied to a lab-scale carbon capture column, allowing its performance to accurately predict that of a larger pilot-scale system. Accurately scaling these technologies is a crucial step for the rapid, widespread deployment of carbon management solutions needed to effectively limit global temperature increase and mitigate the severe impacts of climate change.
This chapter aligns with UN SDG Goals 6 and 13 by discussing advanced water treatment technologies and promoting sustainable water management and climate adaptation strategies.
This chapter aligns with UN SDG Goals 3 and 6 by addressing pollution risks and offering insights for improved water management and policy decisions, ultimately ensuring clean water access and reducing pollution-related health risks.
