Health and population

Health and population dynamics are intertwined, embodying an intricate relationship with significant implications on the Sustainable Development Goals (SDGs). Health is fundamentally at the center of these 17 global goals, aimed to transform the world by 2030. Specifically, Goal 3 endeavors to "Ensure healthy lives and promote well-being for all at all ages." It acknowledges that health is pivotal to human life quality, social cohesion, and sustainable development. Inextricably linked to this are the complexities of population dynamics, including growth rates, age structure, fertility and mortality rates, and migration patterns.

With the world's population projected to exceed 9.7 billion by 2050, the pressure on health systems will undoubtedly escalate. The demographic transition, with an aging population and an increasing prevalence of non-communicable diseases, poses new challenges for health systems globally. Additionally, areas with high fertility rates often overlap with extreme poverty, resulting in heightened health risks, including higher maternal and child mortality rates, malnutrition, and infectious diseases.

Moreover, rapid urbanization and migration present both opportunities and threats to health. While urban areas may provide better access to healthcare, they also harbor risks of disease transmission, air and water pollution, and social determinants of health like inadequate housing and social inequality. Simultaneously, migrants often face disproportionate health risks due to unstable living conditions, exploitation, and limited access to healthcare services.

Achieving the SDGs will necessitate comprehensive approaches that consider the intricate interplay of health and population dynamics. It means strengthening health systems, promoting universal health coverage, and addressing social determinants of health. It also implies crafting policies that recognize demographic realities and foster an environment conducive to sustainable development. Only by understanding and harnessing these dynamics can the world meaningfully progress towards realizing the SDGs, ensuring healthy lives and well-being for all.

Most disease-gene association methods do not account for gene-gene interactions, even though these play a crucial role in complex, polygenic diseases like Alzheimer's disease (AD). To discover new genes whose interactions may contribute to pathology, we introduce GeneEMBED. This approach compares the functional perturbations induced in gene interaction network neighborhoods by coding variants from disease versus healthy subjects. In two independent AD cohorts of 5,169 exomes and 969 genomes, GeneEMBED identified novel candidates.
Elsevier,

The COVID-19 Response
The Vital Role of the Public Health Professional
2023, Pages 101-118

This content aligns with Goal 3: Good Health and Wellbeing as well as Goal 10: Reducing Inequalities by examining the consequences of failing to adequately address long-standing social determinants and structural disparities related to the public's health
Elsevier,

Viruses (Second Edition)
From Understanding to Investigation
2023, Pages 297-300

This content supports the SDG Goal 3: Good health and well-being by exploring the important human pathogen HDV.
Elsevier,

Viruses (Second Edition): From Understanding to Investigation, 2023, Pages 401-407

This content supports the SDG Goal 3: Good health and well-being by exploring the human hepatitis B virus (HBV), family Hepadnaviridae, as a highly infectious virus transmitted by blood and body fluids.
This chapter advances the UN SDG goals 7, 10, and 16 by suggesting that energy does not only need to be democratized but ultimately, needs to be decolonized from the processes that place fossil fuels in the service of settler capitalism, rather than Diné sovereignty. Such a move might enable movements toward energy justice.
This Article supports SDG 3 by highlighting that a substantial proportion of dementia in First Nations peoples in Far North Queensland could potentially be prevented, as half of the burden of dementia in this population may be attributed to 11 potentially modifiable risk factors.
This content aligns with Goal 3: Good Health and Wellbeing as well as Goal 10: Reducing Inequalities by presenting available evidence of the effects of acute COVID-19 illness on children and young people, the impact on at-risk groups, and access to mental health services and education during the pandemic, as well as discussing the implications and recommendations for research, practice, and policy.
Elsevier,

Febrile Seizures (Second Edition)
New Concepts and Consequences
2023, Pages 43-63

This content links with Goal 3: Good health and well-being and Goal 10: Reduced Inequalities by providing important insights informing basic mechanisms underlying febrile seizures.
This content aligns with Goal 3: Good Health and Wellbeing as well as Goal 10: Reducing Inequalities by presenting early evidence on what it meant to be a frail older individual in the COVID-19 pandemic from the perspective of three different settings: community, hospitals, and nursing homes. Lessons learned provide opportunities to improve health outcomes, community and health services, and how we want to live as aging societies.
Elsevier,

Cardio-Hepatology: Connections Between Hepatic and Cardiovascular Disease, 2023, Pages 123-132

Chronic right-sided heart failure has deleterious effects on many organ systems, and the liver is no exception. Passive hepatic congestion not only can precipitate impaired hepatic synthetic function and hepatic fibrosis, but it can also predispose the liver to more severe acute injury in the setting of circulatory compromise, an entity known as hypoxic hepatitis.

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