The paper proposes that Alzheimer's disease may be the consequence of a maladaptation to an evolutionary-based survival pathway triggered by fructose metabolism, which initially helps preserve critical brain functioning during starvation but becomes injurious when engaged for extensive periods. Although more studies are needed on the role of fructose metabolism and its metabolite, uric acid, in Alzheimer’s disease, it is suggested that both dietary and pharmacologic trials to reduce fructose exposure or block fructose metabolism should be performed to determine whether there is potential benefit in the prevention, management, or treatment of this disease.
Our results suggested that the therapeutic effects of NFP on AD were associated with synaptic- and mitochondrial-related pathways, and they provided targets for further rigorous studies on precise understanding of the molecular mechanism of NFP.
This Health Policy article supports Sustainable Development Goal 3 by presenting recommendations for implementation of second-generation memory clinics to assess potentially modifiable risk factors for brain pathology and to reduce risk.
This articles reviews molecular and cellular mechanisms of cell death in neurodegenerative disorders.
The purpose of this study was to investigate barriers in accessing care for infertility in Mexico, because little is known about this issue for low and middle-income countries, which comprise 80% of the world’s population.
This Article supports SDG 3 and 7 by highlighting that that household use of solid fuels for cooking or heating was associated with lower life expectancy in the Chinese population.
Introduction and Objectives: In clinical trials, patients with hepatitis C virus (HCV) genotype (GT)1a infection and baseline resistance-associated substitutions (RASs) at amino acid positions 28, 30,
Over 43 million U.S. residents rely on private unregulated wells for their drinking water, raising public health concerns, particularly in regions like northern New England where widespread groundwater arsenic contamination is now recognized. Children are particularly vulnerable to adverse health effects from arsenic exposure.
In sub-Saharan Africa, many countries have policies and laws that discriminate against men who have sex with men. This paper explores the relationship between these laws and HIV in this key population.
This paper investigates mitochondrial dysfunctions at an early event in the progression of neuropathological processes. It found that that mtDNA mutation is a major contributor to the metabolic pathology of most neurological disorders, causing changes in genes important for physiological homeostasis.
