This study evaluates eight National One Health Strategic Plans using a mixed analytical approach, revealing varying degrees of alignment with core One Health principles and highlighting strengths and gaps to inform future initiatives. The framework combines qualitative, quantitative, and network analyses to assess content, terminology, and conceptual relationships within the plans.
This review highlights how nurse practitioners can strengthen Alzheimer’s disease care by supporting earlier diagnosis and access to treatment, which is essential for maintaining quality of life. Expanding their role helps reduce barriers in the healthcare system, ensuring people with Alzheimer’s receive timely care that promotes better health and well-being.
The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.
The article suggest that beta-amyloid protein (Aβ) has a significant indirect effect on neurogranin (Ng) through key synaptic mediators such as SYT1 and GAP43 during the preclinical stages of Alzheimer’s disease (AD). These findings highlight the crucial role of SYT1 and GAP43 in mediating beta-amyloid-induced synaptic dysfunction, offering potential early biomarkers and therapeutic targets for AD progression.
The article discusses the potential of artificial intelligence (AI) in revolutionizing drug discovery for Alzheimer's disease (AD) and delirium. It explores how AI can facilitate target identification, small molecule and protein-based drug design, and optimization of pharmacokinetic properties to address the challenges in developing effective treatments for these two brain diseases.
World Food Day is a timely opportunity to raise awareness about food allergies. This collection of articles recently published in JACI covers a range of issues and treatments surrounding food allergy
World Food Day is a timely opportunity to raise awareness about food allergies. This collection of articles recently published in JACI covers a range of issues and treatments surrounding food allergy
This study evaluated Universal Free School Meal (UFSM) schemes for 4-11-year-olds in four high-poverty London areas over six years, with longer-term data for two schemes.
The conflict in Sudan since April 2023 has displaced many academics and students, disrupting education and causing financial hardship. The study highlights how war-related inflation and destruction have worsened food insecurity and healthcare destruction, emphasising the urgent need for international aid to support recovery and rebuild the academic sector.
The article examines the experiences and interactions of pregnant and postpartum women with the health system in post-Doi Moi Vietnam.
