Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

Elsevier,

Free Radical Biology and Medicine, Volume 204, 1 August 2023

In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
This study observes that oxidative dame in Alzheimer's Diseases is a pathogenic mechanism at the cell-tissue level.
This content aligns with Goal 3: Good Health and Wellbeing by discussing the medical applications and limitations of five US Food and Drug Administration–approved INSTIs for the treatment of HIV/AIDS and preexposure prophylaxis for HIV-1.
This content aligns with Goal 3: Good Health and Wellbeing by discussing 310 tiglianes reported during 1967–2022, including the mechanisms of action of tiglianes against HIV and discusses the anti-HIV structure–activity relationship of certain tiglianes.
Certain agricultural activities are more associated with depression than others, so there is a need for universal public health surveillance in the agricultural population.
PHQ-8 could be used for screening and severity assesment of depressive symptoms at the European level.
This content aligns with Goal 3: Good Health and Wellbeing by discussing the shifting epidemiology and current management of ESKD in people living with HIV.
This chapter advances the UN SDG goals 3 and 9 by exploring how the Internet of Things can play a future role in curbing pandemic situations.
Elsevier,

Brain Responses to Auditory Mismatch and Novelty Detection
Predictive Coding from Cocktail Parties to Auditory-Related Disorders
2023, Pages 221-269

This content aligns with Goal 3: Good Health and Wellbeing and Goal 10: Reduced Inequalities by highlighting the differences between low- and high-functioning ASD and age dependence of ERP findings in ASD, ADHD, and dyslexia; the effects of language impairment; and the role of ERPs in diagnosing between ASD and ADHD.
World Hepatitis Day takes place every year on 28 July to raise awareness of the global burden of viral hepatitis. To highlight this important disease, Elsevier is proud to host this special collection of book chapters and journal articles which are freely available to download.

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