Neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD), have a global prevalence and profoundly impact both motor and cognitive functions. Although adeno-associated virus (AAV)-based gene therapy has shown promise, its application for treating central nervous system (CNS) diseases faces several challenges, including effective delivery of AAV vectors across the blood-brain barrier, determining optimal dosages, and achieving targeted distribution.
This study shows that the Cognitive Stimulation Therapy program can significantly improve general cognition, communication, and reduce depression in people living with dementia, regardless of the underlying pathology. However, the effects vary by dementia subtype, with some gains maintained long-term in vascular dementia (VaD) but not in Alzheimer, especially regarding narrative abilities and depressive symptoms, highlighting the importance of personalized approaches.
In this review, Hu et al. summarize fluid biomarker findings across 12 anti-amyloid-β clinical trials. The emerging biomarker data provide evidence of impact of the new therapies on the underlying pathophysiological processes of the AD, supporting the presence of a disease-modifying effect.
World-class universities (WCUs) are key players in promoting global sustainability. This study shows that WCU's contributions to global sustainability can be seen in five different dimensions: education and research, outreach and engagement, campus operation and transportation, landscapes and ecosystems, and global leadership and impact evaluation.
This study addresses the solvent scope and perovskite compatibility of acetate-stabilized yttrium-doped SnO2 (Y:SnO2) dispersions.
This study proposes a “Climate-Smart Siting” framework for addressing potential conflicts between renewable energy expansion and biodiversity conservation.
Wind and solar energy in Small Island Developing States for mitigating global climate change This perspective highlights the benefits of developing onshore-offshore wind and solar power for addressing climate change in Small Island Developing States.
This article maps out the magnitude of conflicts between land use and renewable energy.
This article discusses a new strategy to co-locate solar PVs and farms considering the water element.
This system addresses issues arising from insufficient acquisition and sharing of medical information across multiple institutions and sources.
