Elsevier,
The Lancet Rheumatology, Volume 5, September 2023
This Article supports SDG 3 by estimating the burden of osteoarthritis, a major cause of adult disability. The study found that osteoarthritis is the seventh leading cause of years lived with disability worldwide among people older than 70 years. Years lived with disability attributable to osteoarthritis are likely to continue to rise, posing a large challenge to health systems, and necessitating increased focus on preventive and treatment measures.
Elsevier,
The Lancet Healthy Longevity, Volume 4, September 2023
This Article supports SDG 3 by examining the possible effects of hypertension prevention strategies on future dementia and disability occurence. The results suggest that the decrease in dementia and disability due to these interventions is likely to be offset by an increase in the susceptible poulation due to the increase in life expectancy.
Elsevier,
Immunity, Volume 56, 12 September 2023
PLCγ2 is genetically linked to Alzheimer’s disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.
