Elsevier,
Acta Pharmaceutica Sinica B, Volume 15, June 2025
The article discusses the critical role of the mitochondrial contact site and cristae organizing system (MICOS) complex in the pathogenesis of Alzheimer's disease (AD). It highlights how MICOS abnormalities, including subunit dysfunction and interactions with disease-associated proteins, to hallmark AD pathologies such as amyloid-β accumulation, neurofibrillary tangle formation, and neuronal apoptosis. The article suggests that targeting MICOS subunits with pharmacological interventions may provide novel therapeutic insights for AD treatment.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 June 2025
The article discusses the need for and challenges of developing combination therapies for Alzheimer's disease, given the complex and multifactorial nature of the disease. As of 2024, there were 21 combination trials in the pipeline, primarily involving repurposed agents targeting processes like inflammation, senescence, and amyloid-tau interactions. Key challenges include distinguishing individual drug effects and managing the operational complexity of combination trials.f
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 June 2025
This article provides a narrative review of the relationships between modifiable lifestyle factors and plasma biomarkers of Alzheimer's disease (AD). The key findings are that better nutrition, more physical activity, and good sleep quality are associated with more favorable plasma AD biomarker profiles, potentially reflecting less cerebral AD pathology.
Elsevier, Thinking Skills and Creativity, Volume 56, June 2025
This review explores how opportunities for play in public spaces are essential for childrens health and development, with growing research highlighting the links between outdoor play, learning, and the design of playful urban environments.
Elsevier, iScience, Volume 28, 20 June 2025
This study finds that optimal placement of long-duration energy storage in renewable-heavy power systems depends on multiple interacting factorssuch as generation, demand, storage, and transmissionand cannot be determined by any single metric, with siting decisions having system-wide effects.
Elsevier,
Linguistics and Education, Volume 87, June 2025
This study examines how multilingual elementary students use concept maps in an after-school science club to communicate scientific ideas, revealing that they position themselves as competent learners by making flexible language choices and incorporating personal experiences.
Elsevier,
Journal of Nutrition, Health and Aging, Volume 29, June 2025
This study examines the impact of living conditions on cognitive function in older adults in China, and explores the role of plant-based dietary patterns in mitigating the negative effects of poor living conditions. The key finding is that living in fair or poor conditions was associated with an increased risk of developing cognitive impairment, and this association was more pronounced in the "Low-stable-decreasing PDI" group compared to the "High-rapid-decreasing PDI" group.
Elsevier,
World Development Sustainability, Volume 6, June 2025
This study examines the role of women’s leadership in the Wahana Usaha Jaya Cooperative in Bandung, Indonesia, in promoting household food waste reduction and community engagement. Findings show that WUJ’s spiritually motivated and economically empowering strategies effectively encourage waste reduction, particularly among women, despite ongoing infrastructural challenges. The study highlights that women-led, community-based cooperatives offer effective, context-sensitive models for urban environmental governance and advancing food security in the Global South.
