"A diverse range of biochemical and cellular assays are used by medicinal chemists to guide compound optimization. The data collected from these assays influence decisions taken on structure-activity relationship (SAR) campaigns. Therefore, it is paramount that medicinal chemists have a solid understanding of the strengths and limitations of each assay being used to characterize synthesized analogs.
This Perspective Article takes a look at assays relevant to Gaucher, Pompei, Wolman, and Fabry disease, Duchenne muscular dystrophy, and Cystic Fibrosis."
This study explores the pathways from a nutrition-sensitive agriculture intervention to improved diets of women and young children. It also tests theoretical agriculture-to-nutrition pathways by comparing the authors' documented pathways with the pathways from the widely used TANDI (Tackling the Agriculture–Nutrition Disconnect in India) framework.
Gender norms also apply to the expectations around food and cooking. "I am a widow therefore I can cook: I am a widower therefore I need someone to cook for me" is unfounded.
An Article on the impact of the COVID-19 pandemic on the global prevalence of depressive and anxiety disorders in 2020, in the context of SDG 3, highlighting the need for mitigation strategies to promote mental wellbeing and target determinants of poor mental health.
Climate change is both an important social determinant of health (SDH) and a worsening public health threat. Though a warming climate threatens everyone, pediatric populations are particularly vulnerable.
The high rate of SARS-CoV-2 infection poses a serious threat to public health. Previous studies have suggested that SARS-CoV-2 can infect human ovary, the core organ of the female reproductive system. However, it remains unclear which type of ovarian cells are easily infected by SARS-CoV-2 and whether ovarian infectivity differs from puberty to menopause.
The authors' goals of this study (associated with 13 dietary patterns or scenarios) are to assess 1) to what extent current food utilization in Indonesia (2 patterns) provides for meeting health and nutrition targets and how its GHGe (greenhouse gas emissions) and water footprints compare to global targets; and 2) how alternative dietary scenarios, optimized to meet nutrient needs at the lowest possible cost (7 scenarios) or designed to be more healthy and environmentally friendly (4 scenarios), compare to current food patterns for nutrient content, agricultural contributions to climate change, and freshwater conservation, as well as cost.
A Viewpoint on Europe's response to climate change, in the context of SDGs 12, 13, and 17, focusing specifically on the use of region-specific indicators to address the main challenges and opportunities of Europe's response in the context of public and planetary health.
This article examines the role of empathy for outgroup helping, collective action and political activism among youth in Northern Ireland, a setting of protracted conflict.
In this article, we pursue the automatic detection of fake news reporting on the Syrian war using machine learning and meta-learning.
