A Commentary on the role of governments in mitigating the health effects of malnutrition, in the context of SDGs 3 and 12, highlighting the need for the implementation of more comprehensive policies to limit the availability of unhealthy foods and to increase that of healthy foods to communities across Africa.
Background: The COVID-19 pandemic has affected mental health, psychological wellbeing, and social interactions.
Background: Viral hepatitis could have an impact on the treatment response in HIV patients.
The pharmacologic parameters that drive optimal HIV latency reversal in vivo are unknown and could be influenced by such factors as the HDACi binding kinetics, concentration of compound, and duration of exposure. This study evaluates how these parameters affect HIV latency reversal for a series of novel HDACis that differ in their enzymatic on and off rates. The comprehensive data set generated by automating the assays described here was used to establish a PK/PD model for HDACi-induced HIV latency reversal.
Collaborative efforts between public and private entities such as academic institutions, governments, and pharmaceutical companies form an integral part of scientific research, and notable instances of such initiatives have been created within the life science community. Several examples of alliances exist with the broad goal of collaborating toward scientific advancement and improved public welfare. Such collaborations can be essential in catalyzing breaking areas of science within high-risk or global public health strategies that may have otherwise not progressed. A common term used to describe these alliances is public-private partnership (PPP). This review discusses different aspects of such partnerships in drug discovery/development and provides example applications as well as successful case studies. Specific areas that are covered include PPPs for sharing compounds at various phases of the drug discovery process—from compound collections for hit identification to sharing clinical candidates. Instances of PPPs to support better data integration and build better machine learning models are also discussed. The review also provides examples of PPPs that address the gap in knowledge or resources among involved parties and advance drug discovery, especially in disease areas with unfulfilled and/or social needs, like neurological disorders, cancer, and neglected and rare diseases.
In this paper, we address the problem of humanitarian aids distribution across refugee camps in war-ridden areas from a network design perspective.
Problem: Today, one in four children in the world lives in an area of conflict or disaster, and more than 30 million have been displaced, enslaved or trafficked, abused, and exploited.
After a massive disaster, many residents in affected areas are forced to temporarily stay in evacuation shelters.
This Article supports SDGs 3 and 10 by showing how a remote prenatal education package aimed at First Nations pregnant women in Manitoba, Canada, was able to increase prenatal programme participation and breastfeeding initiation in this community. The study shows that such a programme is feasible and effective and can be a useful supplement to existing prenatal programmes in such communities.
