Background: Genetic diversity is a characteristic trait of the hepatitis B virus (HBV) and has been associated with different clinical outcomes.
Cystic fibrosis is a genetic disease affecting more than 70,000 people worldwide. Caused by a mutation in the CFTR gene, cystic fibrosis can result in difficulty breathing, widespread bacterial infections, edema, malnutrition, pancreatitis, and death. Current drug-based treatments struggle to reach the site of action due to the thick mucus, and only manage symptoms such as blocked airways, lung infections, and limited ability to digest food. Nanotechnology opens up possibilities for improved treatment strategies by focusing on drug penetration through the mucus lining, eliminating resulting bacterial infections, and targeting the underlying genetic cause of the disease. In this review, we present recent nanoparticle developments for cystic fibrosis, challenges in nanomedicine therapeutics, and future research directions in gene editing and nonviral vectors for gene delivery.
More than 30 sterols/oxysterols/sterol-acids analysed in human CSF. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate reduced in AD patient-group. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate – an intermediate in bile acid synthesis. Bile acid synthesis linked to AD.
Dementia can disturb the circadian rhythm more than in normal ageing people. And their biological clock is often not enough stimulated by light.
Background: The International Diabetes Federation (IDF) launched the Kids and Diabetes in School (KiDS) project in collaboration with the International Society for Paediatric and Adolescent Diabetes (
The current paper addresses the nature of epistemic injustice as it may be experienced by persons with dementia.
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however, by lingering uncertainty over how to treat the quasi “monogenic” role of apolipoprotein E (APOE).
With growing health risks from rising temperatures in the Global South, the lack of essential indoor cooling is increasingly seen as a dimension of energy poverty and human well-being.
