Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

Alzheimer disease (AD) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. Autophagy is a cellular cleaning process involved in the degradation of proteins, including proteins directly responsible for amyloid plaques, but its activity is compromised in AD. This study showed that reducing dietary protein intake can reduce mTORC1 activity and amyloid plaque deposition in the brains of male mice with a less aggressive model of Alzheimer's disease, but not in a more aggressive model or in female mice.
Elsevier,

Neurochemistry International, Volume 165, May 2023

This review discusses the critical role of oxidative stress in the pathogenesis of neurological disorders such as stroke and Alzheimer's disease (AD), detailing the mechanisms of reactive oxygen species (ROS) generation in the brain and exploring the potential of antioxidant therapies as therapeutic targets.
Elsevier,

Nitric Oxide - Biology and Chemistry, Volume 134-135, 1 May 2023

Nitric Oxide can act as both protecting and aggravating factor in Alzheimer's Disease. Nitric oxide can be considered as a neurotoxic factor in Alzheimer's Disease. Nitric Oxide induces neuro plasticity, neuroprotection, neurogenesis, long-term potentiation, and myelination. Drugs based on Nitric Oxide have shown promising results in Alzheimer's Disease. Nitric Oxide can via sundry ways ameliorate memory formation.
Elsevier, Annals of Hepatology, Volume 28, 1 May 2023
Introduction and Objectives: We aimed to analyze the trends of total and sex-stratified mortality from hepatitis C virus (HCV) and to estimate the proportion of non-alcoholic liver disease deaths in Mexico attributable to HCV from 2001-2017. Materials and Methods: Using the mortality multiple-cause dataset, we selected the codes for acute HCV and chronic HCV to analyze trends from 2001 to 2017.
This study supports SDG 3 by highlighting that coverage of opioid agonist treatment and syringe exchange programmes (which are associated with reducing HIV transmission) are low in most countries and for the majority of people who inject drugs; although coverage is improving, this is insufficient when compared with the indicator targets set out by WHO, UNAIDS, and the UN Office on Drugs and Crime.
This Article supports SDG 3 by analysing follow-up data from over 200 000 people with HIV from 20 cohorts in North America and Europe who had started ART up to 20 years previously, and showing that estimated life expectancy for people with HIV on long-term ART with high CD4 cell counts is only a few years lower than that in the general population, irrespective of when ART was started.
This study assessed the central auditory processing (CAP) function and its electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) and the early stage of Alzheimer's disease (AD) so as to provide a basis for early recognition and intervention of AD.
An insightful paper on the effects that Nordic Walking can have on the cognitive function of patients with mild Alzheimer’s disease.
This chapter aligns with Goal 11: Sustainable cities and communities by adressing methods and regulations for reducing pollution, waste management, traffic, resource utilization, and energy consumption, as well as assuring public safety, a good standard of life, environmental sustainability, and cost management.
Elsevier,

Plotkin's Vaccines (Eighth Edition)
2023, Pages 389-432.e21

This content supports the SDG Goal 3: Good health and well-being by examining current hepatitis B vaccines as a solution toward the elimiation of HBV as a public health treat.

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