South America

This book chapter advances SDG #3 and #10 by reviewing the extant literature on autophagy in AD and covers recent progress on the molecular mechanisms of NAD+-dependent mitophagy/autophagy regulation and mechanisms underlying the anti-AD potential of NAD+. Further studies to define the NAD+-mitophagy/autophagy axis may shed light on novel therapeutics to treat AD and potentially provide insights into other neurodegenerative diseases.

This book chapter advances SDG #3 and #10 by reviewing deep brain stimulation as a treatment for AD patients, reviewing the recent studies and issues associated with the treatment.

In the next 30 years, Alzheimer’s disease cases are predicted to drastically increase. Consequently, there is a critical need for research that can counteract the increasing number of Alzheimer’s disease patients. However, current methods of Alzheimer’s disease research have significant limitations. For example, Alzheimer’s disease research is often restricted by resource, temporal, and recruitment barriers (e.g., participant dropout). Unlike standard research, big data analysis is excellent at investigating complex long-term phenomena such as Alzheimer’s disease.

This book chapter advances SDGs 13, 14, and 15 by presenting a framework for prioritizing future conservation efforts. The chapter ends with a vision of Galapagos tortoise populations 200–300 years from now—as they follow a slow, steady path to full recovery.