Elsevier,
Principles of Gender-Specific Medicine (Fourth Edition)
Sex and Gender-Specific Biology in the Postgenomic Era
2023, Pages 409-429
This content aligns with Goal 3: Good Health and Wellbeing as well as Goal 10: Reduced Inequalities by emphasizing the importance of gender-specific medicine in pharmaceutical development and global healthcare, aiming to improve health outcomes for all genders. By addressing the challenges faced by the pharmaceutical industry in integrating knowledge on sex-specific biological differences into drug development programs, the chapter advocates for strategies to promote equity in healthcare access and outcomes. Additionally, it recognizes the importance of addressing gender disparities in healthcare and advocating for approaches that ensure equal access to gender-specific pharmaceuticals. Through these efforts, the content supports the goal of reducing inequalities in healthcare access and outcomes, ultimately contributing to the promotion of good health and well-being for all individuals, regardless of gender.
The current review seeks to provide a concise overview of the neuropathology and genetics underlying Alzheimer’s disease, and then summarize the most promising clinically available and experimental biomarkers of AD.
This Viewpoint supports Sustainable Development Goal 3 by discussing the effects of the FDA's approval of aducanumab, a treatment for early-stage Alzheimer's disease, despite its limited clinical benefit, as well as the decision of the Centers for Medicare and Medicaid Services to restrict coverage to individuals enrolled in clinical trials. The authors note that these decisions have led to a confusing landscape for patients with Alzheimer's disease.
Cell type-specific transcriptional differences between brain tissues from donors with Alzheimer's disease (AD) and unaffected controls have been well documented, but few studies have rigorously interrogated the regulatory mechanisms responsible for these alterations. We performed single nucleus multiomics (snRNA-seq plus snATAC-seq) on 105,332 nuclei isolated from cortical tissues from 7 AD and 8 unaffected donors to identify candidate cis-regulatory elements (CREs) involved in AD-associated transcriptional changes.
Shaquita Bell, who is both Black and Indigenous, recently became the 33rd Native-identifying full professor of medicine in the USA. Bell's work questions the idea of race as a driver of health outcomes, and aims to improve understanding of race as a social rather than a biological construct.
This study seeks to describe the prevalence and sociodemographic characteristics of community-dwelling older adults experiencing difficulties with understanding others or being understand when communicating in their usual language.
This study shows the communicative practices that facilitate peer socialization processes in an oral classroom for deaf or hard-of-hearing preschoolers.
Elsevier,
Translational Surgery
Handbook for Designing and Conducting Clinical and Translational Research
2023, Pages 591-597
The extensive history of abuse and ongoing mistreatment of Black Americans continues to foster apprehension and distrust of healthcare providers. This has resulted in substantial barriers for modern healthcare to appropriately address the needs of Black patients. These concerns have been visibly manifested during the COVID-19 pandemic. This article supports WHO SDG 3 Good Health and Wellbeing and SDG10 Reduced Inequalities.
Elsevier,
The Thinking Healthcare System
Artificial Intelligence and Human Equity
2023, Pages 99-129
Highlights the 21st century's fundamental “global health” reformulation of PubHealth and anticolonial resistance (to a perceived cultural imperialism of the West including in PubHealth) supporting SDG 3.
In the context of applying machine learning to solve problems for risk prediction, disease detection, and treatment evaluation, EHR pose many challenges– they do not have a consistent, standardized format across institutions particularly in US, can contain human errors and introduce collection biases. In addition, some institutions or geographic regions do not have access to the technology or financial resources necessary to implement EHR, thus resulting in vulnerable and disadvantaged communities not being electronically visible.
